2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101403A
    Monoacetylcadaverine hydrochloride
    Monoacetylcadaverine hydrochloride is a metabolite of the endogenous polyamine cadaverine.
    Monoacetylcadaverine hydrochloride
  • HY-101108S1
    Tazarotenic acid-13C2,d2
    Tazarotenic acid-13C2,d2 (AGN 190299-13C2,d2) is the 13C and deuterium labeled isotope of Tazarotenic acid (HY-101108). Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma.
    Tazarotenic acid-<sup>13</sup>C<sub>2</sub>,d<sub>2</sub>
  • HY-131257
    Gefitinib impurity 1
    		99.59%
    Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.
    Gefitinib impurity 1
  • HY-124320
    Desmethylene paroxetine hydrochloride
    Desmethylene paroxetine hydrochloride is a major urinary metabolite of Paroxetine. Paroxetine is a potent serotonin reuptake inhibitor.
    Desmethylene paroxetine hydrochloride
  • HY-118100
    Cyclo(Tyr-Val)
    Cyclo(Tyr-Val) (Cyclo(L-Tyr-L-Val)) is a diketopiperazine secondary fungal metabolite originally isolated from N. gilva.
    Cyclo(Tyr-Val)
  • HY-14798R
    Palifosfamide (Standard)
    Benzimidazole (Standard) is the analytical standard of Benzimidazole. This product is intended for research and analytical applications. Benzimidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Palifosfamide (Standard)
  • HY-136487
    Buspirone N-oxide
    Buspirone N-oxide (Bu N-oxide) is a metabolite of Buspirone (HY-B1115A). Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research.
    Buspirone N-oxide
  • HY-W424792A
    O-Desmethyl Brinzolamide hydrochloride
    O-Desmethyl Brinzolamide hydrochloride (compound 6a), an active metabolite of Brinzolamide, is a carbonic anhydrase (CA) inhibitor with a Kd of 0.136 nM for CA II and an IC50 of 165 nM for CA IV.
    O-Desmethyl Brinzolamide hydrochloride
  • HY-170056
    2α-Methyl-5α-androstan-17-one-3α-glucuronide
    2α-Methyl-5α-androstan-17-one-3α-glucuronide is a metabolite of Drostanolone.
    2α-Methyl-5α-androstan-17-one-3α-glucuronide
  • HY-12769S1
    Mebeverine acid-d5 hydrochloride
    		≥99.0%
    Mebeverine acid-d5 (hydrochloride) is deuterium labeled Mebeverine acid.
    Mebeverine acid-d<sub>5</sub> hydrochloride
  • HY-176468
    Molidustat glucuronide
    Molidustat glucuronide (BAY-348) is the N-glucuronide metabolite of molidustat (HY-12654). Molidustat glucuronide is primarily formed by glucuronidation and is the only metabolite of molidustat in human and animal plasma. Molidustat glucuronide can be used to study the metabolic pathways and pharmacokinetic properties of molidustat.
    Molidustat glucuronide
  • HY-135563
    Oxoprolintane
    Oxoprolintane is a metabolite of the psychoactive compound Prolintane (HY-124217). Oxoprolintane has a role in regulating the central nervous system and may be a potential neuroprotective agent. Oxoprolintane is expected to be used in research on neurological diseases.
    Oxoprolintane
  • HY-134242A
    6-T-5'-GMP
    6-T-5'-GMP (6-Thioguanosine monophosphate) is an analogue of guanosine-5'-O-monophosphate (5'-GMP) and a metabolite of an immunosuppressive drug, Azathioprine (HY-B0256).
    6-T-5'-GMP
  • HY-17366R
    Clozapine N-oxide (Standard)
    Clozapine N-oxide (Standard) is the analytical standard of Clozapine N-oxide. This product is intended for research and analytical applications. Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].
    Clozapine N-oxide (Standard)
  • HY-133695R
    Florfenicol amine (Standard)
    Florfenicol amine (Standard) is the analytical standard of Florfenicol amine. This product is intended for research and analytical applications. Florfenicol amine is a metabolite of Florfenicol (HY-B1374). Florfenicol, a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases.
    Florfenicol amine (Standard)
  • HY-12784AR
    Cycloguanil (hydrochloride) (Standard)
    Cycloguanil (hydrochloride) (Standard) is the analytical standard of Cycloguanil (hydrochloride). This product is intended for research and analytical applications. Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
    Cycloguanil (hydrochloride) (Standard)
  • HY-135746R
    OR-1896 (Standard)
    7-epi-Taxol (Standard) is the analytical standard of 7-epi-Taxol. This product is intended for research and analytical applications. 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.
    OR-1896 (Standard)
  • HY-118099R
    Florfenicol amine hydrochloride (Standard)
    Florfenicol amine (hydrochloride) (Standard) is the analytical standard of Florfenicol amine (hydrochloride). This product is intended for research and analytical applications. Florfenicol amine hydrochloride is a metabolite of Florfenicol (HY-B1374). Florfenicol inhibits bacterial protein synthesis by binding to 50S and 70S subunits in the ribosome to abolish the activity of peptidyltransferase. Florfenicol, is a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases[1][2].
    Florfenicol amine hydrochloride (Standard)
  • HY-132995A
    DP-1 hydrochloride
    DP-1 hydrochloride, a degradation product of SDC-TRAP-0063, is a fragment of Ganetespib. Ganetespib is a heat shock protein 90 (HSP90) inhibitor with anti-tumor activity.
    DP-1 hydrochloride
  • HY-Y0785
    Glyoxal
    Glyoxal is a cytotoxic α-oxoaldehyde. Glyoxal induces cell damage and promotes protein glycation to form advanced glycation end-products (AGEs). Glyoxal is promising for research of oxidative stress-related diseases (such as atherosclerosis, cataract, Alzheimer's disease), and the formation of calcium oxalate kidney stones.
    Glyoxal
Cat. No. Product Name / Synonyms Application Reactivity